selected Publications

Hollern, D.P., Xu, N., Thennavan, A., Glodowski, C., Garcia-Recio, S., Mott, K.R., He, X., Garay, J.P., Carey-Ewend, K., Marron, D., Ford, J., Liu, S., Vick, S.C., Martin, M., Parker, J.S., Vincent, B.G., Serody, J.S., Perou, C.M. B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer. (2019) Cell. 179(5):1191-1206.e21. DOI: 10.1016/j.cell.2019.10.028

all Publications

Mukherjee, A., Kakati, R.T., Van Alsten, S.C., Laws, T., Ebbs, A.L., Hollern, D.P., Spanheimer, P.M., Hoadley, K.A., Troester, M.A., Simon, J.M., Baldwin, A.S. DAB2IP Loss in Luminal A Breast Cancer Leads to NF-kB Associated Aggressive Oncogenic Phenotypes. (2024) JCI Insight. DOI: 10.1172/jci.insight.171705

To, B., Broeker, C., Jhan, J.R., Garcia-Lerena, J., Vusich, J., Rempel, R., Rennhack, J.P., Hollern, D., Jackson, L., Judah, D., Swiatnicki, M., Bylett, E., Kubiak, R., Honeysett, J., Nevins, J., Andrechek, E. Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model. (2024) Oncogene. DOI: 10.1038/s41388-024-03172-4

Hollern, D. Memory B cell fitness and anergy has significant links to cancer lethality. (2024) Cell. 187(17):4551-4553. DOI: 10.1016/j.cell.2024.07.037

Ramos, M.J., Lui, A.J., Hollern, D.P. The Evolving Landscape of B Cells in Cancer Metastasis. (2023) Cancer Research. DOI: 10.1158/0008-5472.CAN-23-0620

Swiatnicki, M.R., Rennhack, J.P., Ortiz, M.M.O., Hollern, D.P., Perry, A.V., Kubiak, R., Riveria Riveria, S.M., O’Reilly, S., Andrechek, E.R. Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH. (2022) PLOS Genetics. 18(9):e1010362. DOI: 10.1371/journal.pgen.1010362

Laumont, C.M., Banville, A.C., Gilardi, M., Hollern, D.P., Nelson, B.H. Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities. (2022) Nature Reviews Cancer. DOI: 10.1038/s41568-022-00466-1

Singh, S., Lee, N., Pedroza, D.A., Bado, I.L., Hamor, C., Zhang, L., Aguirre, S., Hu, J., Shen, Y., Xu, Y., Gao, Y., Zhao, N., Chen, S.H., Wan, Y.W., Liu, Z., Chang, J.T., Hollern, D., Perou, C.M., Zhang, X.H.F., Rosen, J.M. Chemotherapy coupled to macrophage inhibition induces T-cell and B-cell infiltration and durable regression in triple-negative breast cancer. (2022) Cancer Research. DOI: 10.1158/0008-5472.CAN-21-3714

Bai, F., Wang, C., Liu, X., Hollern, D., Liu, S., Fan, C., Liu, C., Ren, S., Herschkowitz, J.I., Zhu, W.G., Pei, X.H. Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway. (2022) Cell Death & Disease. 13(3):195. DOI: 10.1038/s41419-022-04646-7

Gilardi, M., Saddawi-Konefka, R., Wu, V.H., Lopez-Ramirez, M.A., Wang, Z., Soto, F., Ramms, D.J., Proietto, M., Mikulski, Z., Miki, H., Sharabi, A.B., Kupor, D., Rueda, R., Hollern, D., Wang, J., Gutkind, J.S. Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs. (2022) Molecular Cancer Therapeutics. DOI: 10.1158/1535-7163.MCT-21-0234

Gilardi, M., Ramos, M., Hollern, D. B cells secrete GABA, which provokes a pro-tumor immune microenvironment. (2021) Cancer Cell. DOI: 10.1016/j.ccell.2021.12.007

Garay, J.P., Smith, R., Devlin, K., Hollern, D.P., Liby, T., Liu, M., Boddapati, S., Watson, S.S., Esch, A., Zheng, T., Thompson, W., Babcock, D., Kwon, S., Chin, K., Heiser, L., Gray, J.W., Korkola, J.E. Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA. (2021) Breast Cancer Research. 23(1):81. DOI: 10.1186/s13058-021-01457-0

He, Y., Wang, L., Wei, T., Xiao, Y.T., Sheng, H., Su, H., Hollern, D.P., Zhang, X., Ma, J., Wen, S., Xie, H., Yan, Y., Pan, Y., Hou, X., Tang, X., Suman, V.J., Carter, J.M., Weinshilboum, R., Wang, L., Kalari, K.R., Weroha, S.J., Bryce, A.H., Boughey, J.C., Dong, H., Perou, C.M., Ye, D., Goetz, M.P., Ren, S., Huang, H. FOXA1 overexpression suppresses interferon signaling and immune response in cancer. (2021) Journal of Clinical Investigation. DOI: 10.1172/JCI147025

Bai, F., Liu, S., Liu, X., Hollern, D.P., Scott, A., Wang, C., Zhang, L., Fan, C., Fu, L., Perou, C.M., Zhu, W.G., Pei, X.H. PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors. (2021) Breast Cancer Research. 23(1):10. DOI: 10.1186/s13058-021-01387-x

Garcia-Recio, S., Thennavan, A., East, M.P., Parker, J.S., Cejalvo, J.M., Garay, J.P., Hollern, D.P., He, X., Mott, K.R., Galván, P., Fan, C., Selitsky, S.R., Coffey, A.R., Marron, D., Brasó-Maristany, F., Burgués, O., Albanell, J., Rojo, F., Lluch, A., de Dueñas, E.M., Rosen, J.M., Johnson, G.L., Carey, L.A., Prat, A., Perou, C.M. FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease. (2020) Journal of Clinical Investigation. 130(9):4871-4887. DOI: 10.1172/JCI130323

Crosby, E.J., Acharya, C.R., Haddad, A.F., Rabiola, C.A., Lei, G., Wei, J.P., Yang, X.Y., Wang, T., Liu, C.X., Wagner, K.U., Muller, W.J., Chodosh, L.A., Broadwater, G., Hyslop, T., Shepherd, J.H., Hollern, D.P., He, X., Perou, C.M., Chai, S., Ashby, B.K., Vincent, B.G., Snyder, J.C., Force, J., Morse, M.A., Lyerly, H.K., Hartman, Z.C. Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer. (2020) Clinical Cancer Research. 26(17):4670-4681. DOI: 10.1158/1078-0432.CCR-20-0389

Williams, M., Liu, X., Zhang, Y., Reske, J., Bahal, D., Gohl, T.G., Hollern, D., Ensink, E., Kiupel, M., Luo, R., Das, R., Xiao, H. NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21 overexpression, which is reversed by metformin. (2020) Oncogene. 39(19):3821-3836. DOI: 10.1038/s41388-020-1256-x

Selitsky, S.R., Marron, D., Hollern, D., Mose, L.E., Hoadley, K.A., Jones, C., Parker, J.S., Dittmer, D.P., Perou, C.M. Virus expression detection reveals RNA-sequencing contamination in TCGA. (2020) BMC Genomics. 21(1):79. DOI: 10.1186/s12864-020-6483-6

Hollern, D.P., Xu, N., Thennavan, A., Glodowski, C., Garcia-Recio, S., Mott, K.R., He, X., Garay, J.P., Carey-Ewend, K., Marron, D., Ford, J., Liu, S., Vick, S.C., Martin, M., Parker, J.S., Vincent, B.G., Serody, J.S., Perou, C.M. B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer. (2019) Cell. 179(5):1191-1206.e21. DOI: 10.1016/j.cell.2019.10.028

Hollern, D.P., Swiatnicki, M.R., Rennhack, J.P., Misek, S.A., Matson, B.C., McAuliff, A., Gallo, K.A., Caron, K.M., Andrechek, E.R. E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration. (2019) Scientific Reports. 9(1):10718. DOI: 10.1038/s41598-019-47218-0

Hollern, D.P., Contreras, C.M., Dance-Barnes, S., Silva, G.O., Pfefferle, A.D., Xiong, J., Darr, D.B., Usary, J., Mott, K.R., Perou, C.M. A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer. (2019) Breast Cancer Research and Treatment. 174(1):143-155. DOI: 10.1007/s10549-018-5061-y

Tanioka, M., Mott, K.R., Hollern, D.P., Fan, C., Darr, D.B., Perou, C.M. Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer. (2018) Genome Medicine. 10(1):86. DOI: 10.1186/s13073-018-0597-3

An, Y., Adams, J.R., Hollern, D.P., Zhao, A., Chang, S.G., Gams, M.S., Chung, P.E.D., He, X., Jangra, R., Shah, J.S., Yang, J., Beck, L.A., Raghuram, N., Kozma, K.J., Loch, A.J., Wang, W., Fan, C., Done, S.J., Zacksenhaus, E., Guidos, C.J., Perou, C.M., Egan, S.E. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. (2018) Cell Reports. 25(3):702-714.e6. DOI: 10.1016/j.celrep.2018.09.056

Mukherjee, A., Hollern, D.P., Williams, O.G., Rayburn, T.S., Byrd, W.A., Yates, C., Jones, J.D. A Review of Regulation of Development and Possible Roles in Cancer Progression and Metastasis. (2018) Front Cell Dev Biol. 6:69. DOI: 10.3389/fcell.2018.00069

Shen, H., Shih, J., Hollern, D.P., Wang, L., Bowlby, R., Tickoo, S.K., Thorsson, V., Mungall, A.J., Newton, Y., Hegde, A.M., Armenia, J., Sánchez-Vega, F., Pluta, J., Pyle, L.C., Mehra, R., Reuter, V.E., Godoy, G., Jones, J., Shelley, C.S., Feldman, D.R., Vidal, D.O., Lessel, D., Kulis, T., Cárcano, F.M., Leraas, K.M., Lichtenberg, T.M., Brooks, D., Cherniack, A.D., Cho, J., Heiman, D.I., Kasaian, K., Liu, M., Noble, M.S., Xi, L., Zhang, H., Zhou, W., ZenKlusen, J.C., Hutter, C.M., Felau, I., Zhang, J., Schultz, N., Getz, G., Meyerson, M., Stuart, J.M., ., Akbani, R., Wheeler, D.A., Laird, P.W., Nathanson, K.L., Cortessis, V.K., Hoadley, K.A. Integrated Molecular Characterization of Testicular Germ Cell Tumors. (2018) Cell Reports. 23(11):3392-3406. DOI: 10.1016/j.celrep.2018.05.039

Hollern, D.P., Swiatnicki, M.R., Andrechek, E.R. Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers. (2018) PLOS Genetics. 14(1):e1007135. DOI: 10.1371/journal.pgen.1007135

Acosta, D., Bagchi, S., Broin, P.Ã.“., Hollern, D., Racedo, S.E., Morrow, B., Sellers, R.S., Greally, J.M., Golden, A., Andrechek, E., Wood, T., Montagna, C. LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development. (2016) Scientific Reports. 6:35810. DOI: 10.1038/srep35810

Lunt, S.Y., Muralidhar, V., Hosios, A.M., Israelsen, W.J., Gui, D.Y., Newhouse, L., Ogrodzinski, M., Hecht, V., Xu, K., Acevedo, P.N., Hollern, D.P., Bellinger, G., Dayton, T.L., Christen, S., Elia, I., Dinh, A.T., Stephanopoulos, G., Manalis, S.R., Yaffe, M.B., Andrechek, E.R., Fendt, S.M., Vander Heiden, M.G. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. (2015) Molecular Cell. 57(1):95-107. DOI: 10.1016/j.molcel.2014.10.027

Hollern, D.P., Honeysett, J., Cardiff, R.D., Andrechek, E.R. The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer. (2014) Molecular and Cellular Biology. 34(17):3229-43. DOI: 10.1128/MCB.00737-14

Hollern, D.P., Andrechek, E.R. A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer. (2014) Breast Cancer Research. 16(3):R59. DOI: 10.1186/bcr3672

Chen, F., Li, A., Gao, S., Hollern, D., Williams, M., Liu, F., VanSickle, E.A., Andrechek, E., Zhang, C., Yang, C., Luo, R., Xiao, H. Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. (2014) Cell Death & Disease. 5:e1242. DOI: 10.1038/cddis.2014.224

Hollern, D.P., Yuwanita, I., Andrechek, E.R. A mouse model with T58A mutations in Myc reduces the dependence on KRas mutations and has similarities to claudin-low human breast cancer. (2013) Oncogene. 32(10):1296-304. DOI: 10.1038/onc.2012.142

Zhou, X., Hollern, D., Liao, J., Andrechek, E., Wang, H. NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors. (2013) Cell Death & Disease. 4:e560. DOI: 10.1038/cddis.2013.82

Fujiwara, K., Yuwanita, I., Hollern, D.P., Andrechek, E.R. Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors. (2011) Cancer Research. 71(5):1924-32. DOI: 10.1158/0008-5472.CAN-10-2386